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The PRIO database includes PFAS substances based on several different references. One of the references for PFAS is the US Environmental Protection Agency (US EPA). An update of the PRIO reference PFAS, US EPA has resulted in an additional 3,000 PFAS substances in PRIO. The substances meet the OECD PFAS definition from 2021. In total, the PRIO database now includes 14,000 PFAS substances.
PRIO has been updated with the 2024 reported data from the product register.
In November 2025 the European Chemicals Agency ECHA updated the Candidate List in the REACH Regulation with one new substance:
The twenty-third technical adaptation of the CLP Regulation, ATP 23, has been adopted by the European Commission. With ATP 23, more than 30 substances or groups of substances are added to Annex VI of the CLP Regulation with new or amended EU-harmonised classification and labelling. Based on ATP 23, the PRIO database has been expanded with substances that meet PRIO's criteria for phase-out substances or priority risk reduction substances.
In June 2025 the European Chemicals Agency ECHA updated the Candidate List in the REACH Regulation with 3 new substances.