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PRIO – A tool for Risk Reduction of Chemicals

The criteria in detail

The criteria for the respective property that are used in assessing whether a substance is a phase-out or priority risk-reduction substance follow below.

Phase-out substances

CMR (Carcinogenic (H350*), Mutagenic (H340*) or toxic to Reproduction(H360*)), Category 1A and 1B

PBT/vPvB (Persistent, bioaccumulating and toxic/very persistent and very bioaccumulating)

● Particularly hazardous metals (mercury (Hg), cadmium (Cd), lead (Pb)and their compounds)

Endocrine disruptive

Ozone-depleting (H420, EUH059)

Priority risk-reduction substances

● Very high acute toxicity (health))(H300, H310, H330, H370*)

● Allergenic (H317, H334)

● Mutagenic, Category 2 (H341*)

● High chronic toxicity (health) (H372*)

● Environmentally hazardous, long-term effects (H410, H413)

● Potential PBT/vPvB


According to PRIO, substances under criteria Very high acute toxicity or High chronic toxicity are not considered as phase-out substances. Certainly they can be very harmful even in small doses, but it is possible to handle them in a safe way so that associated risks do not become unacceptable.

Substances considered as phase-out substances are "particularly hazardous substances" as defined in the the Swedish Environmental Quality Objective Non-Toxic Environment, and include CMR cat. 1A, 1B substances, endocrine disruptors, particularly hazardous metals (Hg, Pb, Cd) and PBT / vPvBs substances. Ozone-depleting substances are also considered as phase out substances since the aim of the legislation is to phase them out.

Regarding priority risk reduction substances, the Swedish Chemicals Agency has selected from the classification and labelling criteria (see CLP regulation), substances considered as having a special priority and here are included substances under criteria Very high acute toxicity and High chronic toxicity. Obviously, the possibility of substituting also these substances has to be considered.

The messages or associated phrases for the different priority levels can be found here.



* If it is conclusively proven that no other routes of exposure cause the hazard, the route of exposure can be stated as a part of the hazard statement. Regarding reproductive toxicity the specific effect shall be stated if known (effect on fertility or the unborn child). One or two letters after the hazard statement indicate the route of exposure (e.g. H350i - May cause cancer by inhalation) and/or type of effect. All additional codes are included in the criteria.

 If known, all organs affected can be stated as a part of the hazard statement H370 or H372.