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PRIO – A tool for Risk Reduction of Chemicals


The following sources have been used in collecting example substances for the database when the database was built.

Now we update the PRIO database when the Candidate List of the Reach regulation is updated and when the CLP regulation change because of the new ATPs come into force. The Candidate List is updated twice a year, in June and in December. The update of the PRIO database means that new substances are added or existing substances get a new classification.

The regulation on classification, labelling and packaging, CLP

Annex 1 to Directive 67/548/EEC ceased to apply when Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification and labelling of substances and mixtures (CLP) came into force on 20 January 2009. The binding, harmonised classifications are now found in Annex VI to the CLP Regulation.
To the CLP/GHS-Database

The European Chemicals Agency (Echa) will have a registry open to the public where all substances that are covered by CLP and that are classified as hazardous will be included. The producers and importers own classifications will be available here, as well as all harmonised classifications in the EU. Producers and importers have to give information to the registry from 1 December 2010.

Montreal Protocol

The Montreal Protocol on Substances that deplete the Ozone Layer, UNEP. The international cooperation to protect the ozone layer is governed by a convention under the UN's environmental body, the United Nations Environment Programme (UNEP). The Montreal Protocol, which was signed in 1987, contains binding agreements with regard to the reduction of the use and production of various substances or substance groups that deplete the ozone layer. The Protocol is revised regularly. Following the 1999 supplement, the Montreal Protocol contains a timetable for the phase-out of eight ozone-depleting substances or substance groups.
To the Montreal Protocol


Convention on Long Range Transboundary Air Pollution, UNECE. In 1979, 34 governments and the European Union signed the international Convention on Long-Range Transboundary Air Pollution. In 1983, the Convention was ratified and came into effect. The Convention covers Europe and North America. Part of the Convention is the protocol on persistent organic pollutants (POPs). This covers 16 substances or substance groups (eleven pesticides, two industrial chemicals and three by-products and contaminants). The POP protocol came into effect on 23 October 2003.                                                                                               To LRTAP

Stockholm Convention on Persistent Organic Pollutants (POPs)

The Stockholm Convention (2001) applies worldwide, with the aim of protecting humans and the environment from POPs, i.e. substances that can be transported over long geographical distances before they are broken down. The Stockholm Convention at present contains 21 substances.
To the Stockholm Convention

Regulation 2037/2000/EC

The European Parliament and Council Regulation 2037/2000/EC of 29 June 2000 on substances that deplete the ozone layer. Council Regulation 2037/2000/EC incorporates the Montreal Protocol into European legislation. Under the Montreal Protocol, the EU countries are counted as a single member state with regard to fulfilling the requirements for reductions in ozone-depleting substances. The Council Regulation is stricter than the Montreal Protocol and has a phase-out date earlier than that in the Montreal Protocol.

Defra, 2003

Chemicals Stakeholder Forum's List of Chemicals of Concern, Defra (Department for Environment, Food and Rural Affairs), 2003. Contains persistent, bioaccumulative and toxic high-production-volume chemicals from the IUCLID database (list of substances on the market in the EU) that are used in the United Kingdom. The list was published on the Internet in June 2003 with a plea to industry to supply more information on the substances. The list is not a prohibition list but is intended to draw attention to those substances that have particularly hazardous properties. The list will be regularly revised as better data become available.
To Defra

N-Class, June 2003

N-Class was a database developed by the Nordic Council of Ministers in cooperation with the European Chemicals Bureau (ECB). The database contains  substances that have been discussed by the Commission's working group for the classification and labelling of hazardous substances. The database describes fire, health and environmental hazard classifications for substances that are included in Annex 1 to Council Directive 67/548/EEC on the classification and labelling of dangerous substances. In addition, there was substance-specific information which has formed the basis for the assessment made by the Commission's working groups. This information principally related to environmental effects. The database is no longer being updated.


OSPAR (Oslo and Paris Convention) list of substances of possible concern The OSPAR list contains substances that are persistent, bioaccumulative and toxic or substances judged to have properties of concern. The purpose of the list is to increase transparency in the work on prioritised substances within OSPAR and make it possible to obtain more information on the various substances in the list from the rest of the world. The list is regularly revised as new information becomes available. The list functions as a candidate list to identify substances for the OSPAR list of chemicals for priority action.

NSDB (Nordic Substance Database, 2000)

NSDB contains information on health- and environment-related properties for about 18,000 substances or substance groups from more than 40 sources, e.g. IUCLID, the Swedish Sunset Project (KEMI report 12/95) and various EU lists. The database is no longer being updated.

ECB (European Chemicals Bureau)

An interim strategy for management of PBT and vPvB substances was initiated in June 2001 within the Existing Substance programme. This project aimed to identify PBT and vPvB substances among the high-production-volume chemicals contained in the IUCLID database. The selection criteria has been the same as a Technical Guidance Document (TGD) gives for the assessment of PBTs and vPvBs. The information has been supplemented by data from other databases and studies. The substances in the list has been reviewed by experts from the EU Member States in cooperation with industry. The substances has either been removed from the list or assessed as PBT/vPvB substances. The results from the project were compiled in a data base, "PBT Information System", available at the former ECB website. ECB's mission is finished and some of its activities have been taken over by the European Chemicals Agency (Echa) and the European Commission.

Water Framework Directive (WFD)

Directive 2000/60/EC of the European Parliament and of the Council of 23 October 2000 establishing a framework for Community action in the field of water policy. The Water Framework Directive protects surface waters, i.e. lakes and rivers, ground waters, and coastal waters. The directive sets up a system for water management within river basins. The directive also includes environmental quality standards for priority substances, 45 substances or groups of substances have been identified. However, all 45 substances are not included in the PRIO database because either they don't fulfil the PRIO criteria or they are not classified. The substances with following CAS number are not included in the PRIO database 1806-26-4, 191-24-2, 193-39-5, 206-44-0, 75-09-2, 127-18-4, 12002-48-1, 42576-02-3, 28159-98-0, 886-50-0.
To the Water Framework Directive

Particularly polluting substances in the water management HVMF S 2013:19

This regulation lists substances that are particularly polluting. The substances we have included in the PRIO database are those that have a classification which also include them in the PRIO criteria. Some of the listed substances in the regulation are not covered by the PRIO criteria. The particularly polluting substances listed in the water management that are not in the PRIO database are the following CAS numbers; 7664-41-7; 52-51-7; 83164-33-4; 15307-86-5; 57-63-6; 1071-83-6; 7440-50-8; 16484-77-8; 50-28-2.

Screening Database

The Screening Database is managed by the IVL Swedish Environmental Research Institute on behalf of the Swedish Environmental Protection Agency. The database contains data from the Swedish national environmental monitoring programme area Toxic substance coordination. The data can be used freely if the source is carefully stated.
To the Screening Database

Candidate List, Reach

Substances that are included in the Candidate List have been identified as Substances of Very High Concern (SVHC). Substances on the Candidate List may subsequently become subject to authorisation by decision of the European Commission. More information is available on the European Chemicals Agency´s (Echa) website.
To Echa